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1:  P27172Reports  DNA polymerase...[gi:118888] BLink, Conserved Domains, Links
LOCUS       P27172                  1097 aa            linear   VRL 01-MAY-2007
DEFINITION  DNA polymerase.
ACCESSION   P27172
VERSION     P27172  GI:118888
DBSOURCE    swissprot: locus DPOL_MCMVS, accession P27172;
            class: standard.
            created: Aug 1, 1992.
            sequence updated: Aug 1, 1992.
            annotation updated: May 1, 2007.
            xrefs: M73549.1, AAA45940.1, DJBEMC
            xrefs (non-sequence databases): InterPro:IPR006172,
            InterPro:IPR006133, InterPro:IPR006134, InterPro:IPR012337,
            Gene3D:G3DSA:3.30.420.10, PANTHER:PTHR10322, Pfam:PF00136,
            Pfam:PF03104, PRINTS:PR00106, SMART:SM00486, PROSITE:PS00116
KEYWORDS    DNA replication; DNA-binding; DNA-directed DNA polymerase; Nuclear
            protein; Nucleotidyltransferase; Transferase.
SOURCE      Murine cytomegalovirus (strain Smith)
  ORGANISM  Murine cytomegalovirus (strain Smith)
            Viruses; dsDNA viruses, no RNA stage; Herpesviridae;
            Betaherpesvirinae; Muromegalovirus.
REFERENCE   1  (residues 1 to 1097)
  AUTHORS   Elliott,R., Clark,C., Jaquish,D. and Spector,D.H.
  TITLE     Transcription analysis and sequence of the putative murine
            cytomegalovirus DNA polymerase gene
  JOURNAL   Virology 185 (1), 169-186 (1991)
   PUBMED   1718083
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
COMMENT     On Jul 5, 2005 this sequence version replaced gi:67043.
            [CATALYTIC ACTIVITY] Deoxynucleoside triphosphate + DNA(n) =
            diphosphate + DNA(n+1).
            [SUBCELLULAR LOCATION] Nucleus.
            [SIMILARITY] Belongs to the DNA polymerase type-B family.
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Murine cytomegalovirus (strain Smith)"
                     /specific_host="Mus musculus (Mouse)"
                     /db_xref="taxon:10367"
     gene            1..1097
                     /gene="UL54"
     Protein         1..1097
                     /gene="UL54"
                     /product="DNA polymerase"
                     /EC_number="2.7.7.7"
     Region          1..1097
                     /gene="UL54"
                     /region_name="Mature chain"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="DNA polymerase. /FTId=PRO_0000046508."
     Region          130..>154
                     /gene="UL54"
                     /region_name="DNA_pol_B_exo"
                     /note="DNA polymerase family B, exonuclease domain. This
                     domain has 3' to 5' exonuclease activity and adopts a
                     ribonuclease H type fold; pfam03104"
                     /db_xref="CDD:66758"
     Region          284..834
                     /gene="UL54"
                     /region_name="POLBc"
                     /note="DNA polymerase type-B family; DNA directed DNA
                     polymerase. Posseses DNA binding, polymerase and 3'-5'
                     exonuclease activity; cd00145"
                     /db_xref="CDD:29064"
     Region          284..796
                     /gene="UL54"
                     /region_name="POLBc"
                     /note="DNA polymerase type-B family; DNA polymerase alpha,
                     delta, epsilon and zeta chain (eukaryota), DNA polymerases
                     in archaea, DNA polymerase II in e; smart00486"
                     /db_xref="CDD:47792"
     Region          543..1050
                     /gene="UL54"
                     /region_name="DNA_pol_B"
                     /note="DNA polymerase family B. This region of DNA
                     polymerase B appears to consist of more than one
                     structural domain, possibly including elongation,
                     DNA-binding and dNTP binding activities; pfam00136"
                     /db_xref="CDD:64022"
ORIGIN      
        1 mdtcvetffn pylrrkprrd wrrcednnkn flqvvprgvl ydgatglikv qsgmeprmfy
       61 aekeyvlnpd kpwptlrtrg wcrgpysddv rfhtydqvvn lvladsdeqi sprwnshvvp
      121 agnvirmfga tdegvsvcvn vfgqkayfyc ermqsedlkn tvydiadkvp epcspfsvsi
      181 spvtkssfyg yglghipnly rlsfnnwnmc rkigkrmlee grkvyelgvd plarflidrk
      241 ipsfgwclar rysvraagyv sraqleidcd vadilpieeq snwpfyrcls fdiecmsgtg
      301 afpaaenvdd iiiqiscvcf gvgemvhhay dvhadlstpa vpenhlftig pcapipdvki
      361 ytfpseyeml rgffiflswy spefitgyni ngfdikyilt raeklykmdv gqftklrrgg
      421 rmfvfspekg kagfgtsntv kvfwsgtvvl dmypvctaka sspnykldtm aeiylkkkkd
      481 dlsykeipvq fsagdegrap ggkyclqdav lvrelfemla fhfeaaaiar lariplrkvi
      541 fdgqqiriyt clleecsgrd milpnmpslg hgaaaaieea aaggegdets egensnnsrt
      601 vgyqgatvle pecgfhhvpv cvfdfaslyp siimsnnlcy stllvegspe vpekdvlrve
      661 igdqchrfvr envhrsllae llvrwltqrk lvreamkqct nemqrmimdk qqlalkvtcn
      721 afygftgvaa gmlpclpiaa sitkigrdml lataghiedr cnrpdflrtv lglppeaidp
      781 ealrvkiiyg dtdsvfaafy gidkeallka vgalaanvtn alfkepvrle fekmfvslmm
      841 ickkryigkv hgsqnlsmkg vdlvrrtacg fvkavvsdvl hmvfndetvs egtmklsrmt
      901 fddlkkngip cefgpvvsrl crarddlhlk kvpvpeltls svlsqelscy kqknlphlav
      961 irrlaarkee lpavgdrvey vltlpdgckk nvpnyeiaed prhvveakls inaekyyeqv
     1021 vkavtntlmp vfprdmpkre kffslvvpqr iyipdqflhl cgnvnelarg gddsdggdse
     1081 kenmdterss sheamet
//

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