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1:  P08546Reports  DNA polymerase...[gi:1169409] BLink, Conserved Domains, Links
LOCUS       P08546                  1242 aa            linear   VRL 01-MAY-2007
DEFINITION  DNA polymerase.
ACCESSION   P08546
VERSION     P08546  GI:1169409
DBSOURCE    swissprot: locus DPOL_HCMVA, accession P08546;
            class: standard.
            extra accessions:Q7M6M9
            created: Aug 1, 1988.
            sequence updated: Nov 1, 1995.
            annotation updated: May 1, 2007.
            xrefs: X17403.1, CAA35413.1, M17209.1, AAA46008.1, M14709.1,
            AAA45988.1, BK000394.1, DAA00159.1, DJBEC1, 1YYPB
            xrefs (non-sequence databases): DrugBank:APRD00148,
            DrugBank:APRD00669, InterPro:IPR006172, InterPro:IPR006133,
            InterPro:IPR006134, InterPro:IPR012337, Gene3D:G3DSA:3.30.420.10,
            PANTHER:PTHR10322, Pfam:PF00136, Pfam:PF03104, PRINTS:PR00106,
            SMART:SM00486, PROSITE:PS00116
KEYWORDS    3D-structure; DNA replication; DNA-binding; DNA-directed DNA
            polymerase; Nuclear protein; Nucleotidyltransferase; Transferase;
            Virion protein.
SOURCE      Human herpesvirus 5 strain AD169
  ORGANISM  Human herpesvirus 5 strain AD169
            Viruses; dsDNA viruses, no RNA stage; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (residues 1 to 1242)
  AUTHORS   Kouzarides,T., Bankier,A.T., Satchwell,S.C., Weston,K.,
            Tomlinson,P. and Barrell,B.G.
  TITLE     Sequence and transcription analysis of the human cytomegalovirus
            DNA polymerase gene
  JOURNAL   J. Virol. 61 (1), 125-133 (1987)
   PUBMED   3023690
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   2  (residues 1 to 1242)
  AUTHORS   Kouzarides,T., Bankier,A.T., Satchwell,S.C., Weston,K.,
            Tomlinson,P. and Barrell,B.G.
  TITLE     Large-scale rearrangement of homologous regions in the genomes of
            HCMV and EBV
  JOURNAL   Virology 157 (2), 397-413 (1987)
   PUBMED   3029980
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   3  (residues 1 to 1242)
  AUTHORS   Chee,M.S., Bankier,A.T., Beck,S., Bohni,R., Brown,C.M., Cerny,R.,
            Horsnell,T., Hutchison,C.A. III, Kouzarides,T., Martignetti,J.A.,
            Preddie,E., Satchwell,S.C., Tomlinson,P., Weston,K.M. and
            Barrell,B.G.
  TITLE     Analysis of the protein-coding content of the sequence of human
            cytomegalovirus strain AD169
  JOURNAL   Curr. Top. Microbiol. Immunol. 154, 125-169 (1990)
   PUBMED   2161319
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   4  (residues 1 to 1242)
  AUTHORS   Davison,A.J., Dolan,A., Akter,P., Addison,C., Dargan,D.J.,
            Alcendor,D.J., McGeoch,D.J. and Hayward,G.S.
  TITLE     The human cytomegalovirus genome revisited: comparison with the
            chimpanzee cytomegalovirus genome
  JOURNAL   J. Gen. Virol. 84 (PT 1), 17-28 (2003)
   PUBMED   12533697
  REMARK    GENOME REANNOTATION.
            Erratum:[J Gen Virol. 2003 Apr;84(Pt 4):1053]
REFERENCE   5  (residues 1 to 1242)
  AUTHORS   Davison,A.J., Dolan,A., Akter,P., Addison,C., Dargan,D.J.,
            Alcendor,D.J., McGeoch,D.J. and Hayward,G.S.
  JOURNAL   J. Gen. Virol. 84, 1053-1053 (2003)
  REMARK    ERRATUM.
REFERENCE   6  (residues 1 to 1242)
  AUTHORS   Varnum,S.M., Streblow,D.N., Monroe,M.E., Smith,P., Auberry,K.J.,
            Pasa-Tolic,L., Wang,D., Camp,D.G. II, Rodland,K., Wiley,S.,
            Britt,W., Shenk,T., Smith,R.D. and Nelson,J.A.
  TITLE     Identification of proteins in human cytomegalovirus (HCMV)
            particles: the HCMV proteome
  JOURNAL   J. Virol. 78 (20), 10960-10966 (2004)
   PUBMED   15452216
  REMARK    IDENTIFICATION.
            Erratum:[J Virol. 2004 Dec;78(23):13395]
REFERENCE   7  (residues 1 to 1242)
  AUTHORS   Varnum,S.M., Streblow,D.N., Monroe,M.E., Smith,P., Auberry,K.J.,
            Pasa-Tolic,L., Wang,D., Camp,D.G.I.I., Rodland,K., Wiley,S.,
            Britt,W., Shenk,T., Smith,R.D. and Nelson,J.A.
  JOURNAL   J. Virol. 78, 13395-13395 (2004)
  REMARK    ERRATUM.
COMMENT     On or before Apr 12, 2005 this sequence version replaced gi:67042,
            gi:118860.
            [CATALYTIC ACTIVITY] Deoxynucleoside triphosphate + DNA(n) =
            diphosphate + DNA(n+1).
            [SUBCELLULAR LOCATION] Nucleus.
            [MISCELLANEOUS] Found in the virion.
            [SIMILARITY] Belongs to the DNA polymerase type-B family.
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Human herpesvirus 5 strain AD169"
                     /specific_host="Homo sapiens (Human)"
                     /db_xref="taxon:10360"
     gene            1..1242
                     /gene="UL54"
                     /note="synonym: HFLF2"
     Protein         1..1242
                     /gene="UL54"
                     /product="DNA polymerase"
                     /EC_number="2.7.7.7"
     Region          1..1242
                     /gene="UL54"
                     /region_name="Mature chain"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="DNA polymerase. /FTId=PRO_0000046507."
     Region          139..>163
                     /gene="UL54"
                     /region_name="DNA_pol_B_exo"
                     /note="DNA polymerase family B, exonuclease domain. This
                     domain has 3' to 5' exonuclease activity and adopts a
                     ribonuclease H type fold; pfam03104"
                     /db_xref="CDD:66758"
     Region          293..>612
                     /gene="UL54"
                     /region_name="POLBc"
                     /note="DNA polymerase type-B family; DNA directed DNA
                     polymerase. Posseses DNA binding, polymerase and 3'-5'
                     exonuclease activity; cd00145"
                     /db_xref="CDD:29064"
     Region          684..1224
                     /gene="UL54"
                     /region_name="DNA_pol_B"
                     /note="DNA polymerase family B. This region of DNA
                     polymerase B appears to consist of more than one
                     structural domain, possibly including elongation,
                     DNA-binding and dNTP binding activities; pfam00136"
                     /db_xref="CDD:64022"
     Region          <684..953
                     /gene="UL54"
                     /region_name="POLBc"
                     /note="DNA polymerase type-B family; DNA directed DNA
                     polymerase. Posseses DNA binding, polymerase and 3'-5'
                     exonuclease activity; cd00145"
                     /db_xref="CDD:29064"
     Region          942..943
                     /gene="UL54"
                     /region_name="Conflict"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="FV -> VF (in Ref. 3)."
ORIGIN      
        1 mffnpylsgg vtggavaggr rqrsqpgsaq gsgkrppqkq flqivprgvm fdgqtglikh
       61 ktgrlplmfy reikhllshd mvwpcpwret lvgrvvgpir fhtydqtdav lffdspenvs
      121 pryrqhlvps gnvlrffgat ehgysicvnv fgqrsyfyce ysdtdrlrev iasvgelvpe
      181 prtpyavsvt patktsiygy gtrpvpdlqc vsisnwtmar kigeylleqg fpvyevrvdp
      241 ltrlvidrri ttfgwcsvnr ydwrqqgras tcdievdcdv sdlvavpdds swpryrclsf
      301 diecmsgegg fpcaeksddi viqiscvcye tggntavdqg ipngndgrgc tsegvifghs
      361 glhlftigtc gqvgpdvdvy efpseyelll gfmlffqrya pafvtgynin sfdlkyiltr
      421 leylykvdsq rfcklptaqg grfflhspav gfkrqyaaaf psashnnpas taatkvyiag
      481 svvidmypvc maktnspnyk lntmaelylr qrkddlsykd iprcfvanae graqvgrycl
      541 qdavlvrdlf ntinfhyeag aiarlakipl rrvifdgqqi riytslldec acrdfilpnh
      601 yskgttvpet nsvavspnaa iistaavpgd agsvaamfqm spplqsapss qdgvspgsgs
      661 nssssvgvfs vgsgssggvg vsndnhgagg taavsyqgat vfepevgyyn dpvavfdfas
      721 lypsiimahn lcystllvpg geypvdpadv ysvtlengvt hrfvrasvrv svlsellnkw
      781 vsqrravrec mrecqdpvrr mlldkeqmal kvtcnafygf tgvvngmmpc lpiaasitri
      841 grdmlertar fikdnfsepc flhnffnqed yvvgtregds eessalpegl etssggsner
      901 rvearviygd tdsvfvrfrg ltpqalvarg pslahyvtac lfvepvklef ekvfvslmmi
      961 ckkryigkve gasglsmkgv dlvrktacef vkgvtrdvls llfedrevse aavrlsrlsl
     1021 devkkygvpr gfwrilrrlv qarddlylhr vrvedlvlss vlskdislyr qsnlphiavi
     1081 krlaarseel psvgdrvfyv ltapgvrtap qgssdngdsv tagvvsrsda idgtdddadg
     1141 ggveesnrrg gepakkrark ppsavcnyev aedpsyvreh gvpihadkyf eqvlkavtnv
     1201 lspvfpgget arkdkflhmv lprrlhlepa flpysvkahe cc
//

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