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1:  P04293Reports  DNA polymerase...[gi:118878] BLink, Conserved Domains, Links
LOCUS       P04293                  1235 aa            linear   VRL 01-MAY-2007
DEFINITION  DNA polymerase.
ACCESSION   P04293
VERSION     P04293  GI:118878
DBSOURCE    swissprot: locus DPOL_HHV11, accession P04293;
            class: standard.
            created: Mar 20, 1987.
            sequence updated: Jul 1, 1989.
            annotation updated: May 1, 2007.
            xrefs: X14112.1, CAA32323.1, X03181.1, CAA26941.1, DJBEV1, DJBEH7
            xrefs (non-sequence databases): DrugBank:APRD00567,
            DrugBank:APRD00600, DrugBank:APRD00669, DrugBank:APRD00263,
            DrugBank:APRD00504, DrugBank:APRD00041, DrugBank:APRD01275,
            DrugBank:APRD00697, InterPro:IPR006172, InterPro:IPR006133,
            InterPro:IPR006134, InterPro:IPR012337, Gene3D:G3DSA:3.30.420.10,
            PANTHER:PTHR10322, Pfam:PF00136, Pfam:PF03104, PRINTS:PR00106,
            SMART:SM00486, PROSITE:PS00116
KEYWORDS    DNA replication; DNA-binding; DNA-directed DNA polymerase; Nuclear
            protein; Nucleotidyltransferase; Transferase.
SOURCE      Herpes simplex virus (type 1 / strain 17)
  ORGANISM  Herpes simplex virus (type 1 / strain 17)
            Viruses; dsDNA viruses, no RNA stage; Herpesviridae;
            Alphaherpesvirinae; Simplexvirus.
REFERENCE   1  (residues 1 to 1235)
  AUTHORS   McGeoch,D.J., Dalrymple,M.A., Davison,A.J., Dolan,A., Frame,M.C.,
            McNab,D., Perry,L.J., Scott,J.E. and Taylor,P.
  TITLE     The complete DNA sequence of the long unique region in the genome
            of herpes simplex virus type 1
  JOURNAL   J. Gen. Virol. 69 (PT 7), 1531-1574 (1988)
   PUBMED   2839594
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   2  (residues 1 to 1235)
  AUTHORS   Quinn,J.P. and McGeoch,D.J.
  TITLE     DNA sequence of the region in the genome of herpes simplex virus
            type 1 containing the genes for DNA polymerase and the major DNA
            binding protein
  JOURNAL   Nucleic Acids Res. 13 (22), 8143-8163 (1985)
   PUBMED   2999714
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
COMMENT     On or before Oct 25, 2005 this sequence version replaced gi:67037,
            gi:67038.
            [CATALYTIC ACTIVITY] Deoxynucleoside triphosphate + DNA(n) =
            diphosphate + DNA(n+1).
            [SUBCELLULAR LOCATION] Nucleus.
            [SIMILARITY] Belongs to the DNA polymerase type-B family.
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Herpes simplex virus (type 1 / strain 17)"
                     /specific_host="Homo sapiens (Human)"
                     /db_xref="taxon:10299"
     gene            1..1235
                     /gene="UL30"
     Protein         1..1235
                     /gene="UL30"
                     /product="DNA polymerase"
                     /EC_number="2.7.7.7"
     Region          1..1235
                     /gene="UL30"
                     /region_name="Mature chain"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="DNA polymerase. /FTId=PRO_0000046511."
     Region          114..126
                     /gene="UL30"
                     /region_name="Conflict"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="VLRVGSGGFWPRR -> APPRRVGRLLAAA (in Ref. 2)."
     Region          360..928
                     /gene="UL30"
                     /region_name="POLBc"
                     /note="DNA polymerase type-B family; DNA directed DNA
                     polymerase. Posseses DNA binding, polymerase and 3'-5'
                     exonuclease activity; cd00145"
                     /db_xref="CDD:29064"
     Region          616..1195
                     /gene="UL30"
                     /region_name="DNA_pol_B"
                     /note="DNA polymerase family B. This region of DNA
                     polymerase B appears to consist of more than one
                     structural domain, possibly including elongation,
                     DNA-binding and dNTP binding activities; pfam00136"
                     /db_xref="CDD:64022"
ORIGIN      
        1 mfsggggpls pggksaaraa sgffapagpr gasrgpppcl rqnfynpyla pvgtqqkptg
       61 ptqrhtyyse cdefrfiapr vldedappek ragvhdghlk rapkvycggd erdvlrvgsg
      121 gfwprrsrlw ggvdhapagf nptvtvfhvy dilenvehay gmraaqfhar fmdaitptgt
      181 vitllgltpe ghrvavhvyg trqyfymnke evdrhlqcra prdlcermaa alrespgasf
      241 rgisadhfea evvertdvyy yetrpalfyr vyvrsgrvls ylcdnfcpai kkyeggvdat
      301 trfildnpgf vtfgwyrlkp grnntlaqpa apmafgtssd vefnctadnl aieggmsdlp
      361 ayklmcfdie ckaggedela fpvaghpedl viqiscllyd lsttalehvl lfslgscdlp
      421 eshlnelaar glptpvvlef dsefemllaf mtlvkqygpe fvtgyniinf dwpfllaklt
      481 diykvpldgy grmngrgvfr vwdigqshfq krskikvngm vnidmygiit dkiklssykl
      541 navaeavlkd kkkdlsyrdi payyaagpaq rgvigeyciq dsllvgqlff kflphlelsa
      601 varlaginit rtiydgqqir vftcllrlad qkgfilpdtq grfrgaggea pkrpaaared
      661 eerpeeeged edereeggge repegareta grhvgyqgar vldptsgfhv npvvvfdfas
      721 lypsiiqahn lcfstlslra davahleagk dyleievggr rlffvkahvr esllsillrd
      781 wlamrkqirs ripqsspeea vlldkqqaai kvvcnsvygf tgvqhgllpc lhvaatvtti
      841 gremllatre yvharwaafe qlladfpeaa dmrapgpysm riiygdtdsi fvlcrgltaa
      901 gltavgdkma shisralflp piklecektf tkllliakkk yigviyggkm likgvdlvrk
      961 nncafinrts ralvdllfyd dtvsgaaaal aerpaeewla rplpeglqaf gavlvdahrr
     1021 itdperdiqd fvltaelsrh praytnkrla hltvyyklma rraqvpsikd ripyvivaqt
     1081 reveetvarl aalreldaaa pgdepappaa lpspakrpre tpspadppgg askprkllvs
     1141 elaedpayai ahgvalntdy yfshllgaac vtfkalfgnn akitesllkr fipevwhppd
     1201 dvaarlrtag fgavgagata eetrrmlhra fdtla
//

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