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1:  NP_006506Reports  SET domain and ma...[gi:5730039] BLink, Conserved Domains, Links
LOCUS       NP_006506                671 aa            linear   PRI 11-MAR-2007
DEFINITION  SET domain and mariner transposase fusion [Homo sapiens].
VERSION     NP_006506.1  GI:5730039
DBSOURCE    REFSEQ: accession NM_006515.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 671)
  AUTHORS   Liu,D., Bischerour,J., Siddique,A., Buisine,N., Bigot,Y. and
  TITLE     The human SETMAR protein preserves most of the activities of the
            ancestral Hsmar1 transposase
  JOURNAL   Mol. Cell. Biol. 27 (3), 1125-1132 (2007)
   PUBMED   17130240
  REMARK    GeneRIF: SETMAR is unlikely to catalyze transposition in the human
            genome, although the nicking activity may have a role in the DNA
            repair phenotype.
REFERENCE   2  (residues 1 to 671)
  AUTHORS   Keravala,A., Liu,D., Lechman,E.R., Wolfe,D., Nash,J.A., Lampe,D.J.
            and Robbins,P.D.
  TITLE     Hyperactive Himar1 transposase mediates transposition in cell
            culture and enhances gene expression in vivo
  JOURNAL   Hum. Gene Ther. 17 (10), 1006-1018 (2006)
   PUBMED   16989604
  REMARK    GeneRIF: These data suggest that vectors based on the Himar1
            transposable element, in conjunction with the hyperactive mutant
            transposase C9, may be suitable vectors for gene therapy
REFERENCE   3  (residues 1 to 671)
  AUTHORS   Lee,S.H., Oshige,M., Durant,S.T., Rasila,K.K., Williamson,E.A.,
            Ramsey,H., Kwan,L., Nickoloff,J.A. and Hromas,R.
  TITLE     The SET domain protein Metnase mediates foreign DNA integration and
            links integration to nonhomologous end-joining repair
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (50), 18075-18080 (2005)
   PUBMED   16332963
  REMARK    GeneRIF: Metnase is a nonhomologous end-joining repair protein that
            regulates genomic integration of exogenous DNA and establishes a
            relationship among histone modification, DNA repair, and
REFERENCE   4  (residues 1 to 671)
  AUTHORS   Robertson,H.M. and Zumpano,K.L.
  TITLE     Molecular evolution of an ancient mariner transposon, Hsmar1, in
            the human genome
  JOURNAL   Gene 205 (1-2), 203-217 (1997)
   PUBMED   9461395
REFERENCE   5  (residues 1 to 671)
  AUTHORS   Berry,R., Stevens,T.J., Walter,N.A., Wilcox,A.S., Rubano,T.,
            Hopkins,J.A., Weber,J., Goold,R., Soares,M.B. and Sikela,J.M.
  TITLE     Gene-based sequence-tagged-sites (STSs) as the basis for a human
            gene map
  JOURNAL   Nat. Genet. 10 (4), 415-423 (1995)
   PUBMED   7670491
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U80776.1.
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
     Protein         1..671
                     /product="SET domain and mariner transposase fusion"
     Region          14..110
                     /note="N-terminal to some SET domains; A Cys-rich putative
                     Zn2+-binding domain that occurs N-terminal to some SET
                     domains. Function is unknown. Unpublished; smart00468"
     Region          126..255
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain; Putative methyl transferase, based on outlier
                     plant homologues; smart00317"
     Region          488..568
                     /note="Transposase. This family includes the mariner
                     transposase; pfam01359"
     CDS             1..671
                     /GO_function="DNA binding; histone-lysine
                     N-methyltransferase activity; transposase activity [pmid
                     9461395]; zinc ion binding"
                     /GO_process="chromatin modification; regulation of
                     transcription; transposition, DNA-mediated [pmid 9461395]"
        1 maefkekpea pteqldvacg qenlpvgawp pgaapapfqy tpdhvvgpga didptqitfp
       61 gcicvktpcl pgtcsclrhg enyddnsclr digsggkyae pvfecnvlcr csdhcrnrvv
      121 qkglqfhfqv fkthkkgwgl rtlefipkgr fvceyagevl gfsevqrrih lqtksdsnyi
      181 iairehvyng qvmetfvdpt yignigrfln hscepnllmi pvridsmvpk lalfaakdiv
      241 peeelsydys grylnltvsa skerldhgkl rkpcycgaks ctaflpfdss lycpveksni
      301 scgnekepsm cgsapsvfps ckrltletmk mmldkkqira iflfefkmgr kaaettrnin
      361 nafgpgtane rtvqwwfkkf ckgdeslede ersgrpsevd ndqlraiiea dpltttreva
      421 eelnvnhstv vrhlkqiekv kkldkwvphe ltenqknrrf evssslilrn hnepfldriv
      481 tcdekwilyd nrrrsaqwld qeeapkhfpk pilhpkkvmv tiwwsaagli hysflnpget
      541 itsekyaqei demnqklqrl qlalvnrkgp illhdnarph vaqptlqkln elgyevlphp
      601 pyspdllptn yhvfkhlnnf lqgkrfhnqq daenafqefv esqstdfyat ginqlisrwq
      661 kcvdcngsyf d

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